Dr. Craighead has led an active research program in nanofabrication and the science of nanoscale systems, with recent emphasis on biotechnology. He has explored methods for single biomolecule manipulation, detection and analysis. He has published over 400 research papers and book chapters and has 75 issued U.S. patents. He has organized and chaired a number of conferences and symposia on nanostructure science and technology. He was also part of the group that prepared the report leading to the original National Nanotechnology Initiative. His educational activity includes the development and teaching of courses from the freshman to graduate levels in nanostructure science and engineering. In 2000 he co-founded Nanofluidics Inc., now Pacific Biosciences, a company that has commercialized methods for single-molecule DNA sequencing.